DetoxFungiV1, Main, Exploration, bibRecord, 001661

A genetic approach to study H2O2 scavenging in fission yeast--distinct roles of peroxiredoxin and catalase.

Identifieur interne : 001661 ( Main/Exploration ); précédent : 001660; suivant : 001662

A genetic approach to study H2O2 scavenging in fission yeast--distinct roles of peroxiredoxin and catalase.

Auteurs : Esther Paulo [Espagne] ; Sarela García-Santamarina ; Isabel A. Calvo ; Mercè Carmona ; Susanna Boronat ; Alba Domènech ; José Ayté ; Elena Hidalgo

Source :

Molecular microbiology [ 1365-2958 ] ; 2014.

RBID : pubmed:24521463

Descripteurs français

English descriptors

KwdEn :
- Aerobiosis (MeSH), Anaerobiosis (MeSH), Basic-Leucine Zipper Transcription Factors (metabolism), Catalase (metabolism), Gene Deletion (MeSH), Gene Expression Regulation, Fungal (MeSH), Hydrogen Peroxide (metabolism), Oxygen (metabolism), Pancreatitis-Associated Proteins (MeSH), Peroxiredoxins (genetics), Peroxiredoxins (metabolism), Schizosaccharomyces (genetics), Schizosaccharomyces (metabolism), Schizosaccharomyces pombe Proteins (genetics), Schizosaccharomyces pombe Proteins (metabolism), Thioredoxin-Disulfide Reductase (genetics).
MESH :
- chemical , genetics : Peroxiredoxins, Schizosaccharomyces pombe Proteins, Thioredoxin-Disulfide Reductase.
- chemical , metabolism : Basic-Leucine Zipper Transcription Factors, Catalase, Hydrogen Peroxide, Oxygen, Peroxiredoxins, Schizosaccharomyces pombe Proteins.
- genetics : Schizosaccharomyces.
- metabolism : Schizosaccharomyces.
- Aerobiosis, Anaerobiosis, Gene Deletion, Gene Expression Regulation, Fungal, Pancreatitis-Associated Proteins.

Abstract

The main peroxiredoxin in Schizosaccharomyces pombe, Tpx1, is important to sustain aerobic growth, and cells lacking this protein are only able to grow on solid plates under anaerobic conditions. We have found that deletion of the gene coding for thioredoxin reductase, trr1, is a suppressor of the sensitivity to aerobic growth of Δtpx1 cells, so that cells lacking both proteins are able to grow on solid plates in the presence of oxygen. We have investigated this suppression effect, and determined that it depends on the presence of catalase, which is constitutively expressed in Δtrr1 cells in a transcription factor Pap1-dependent manner. A complete characterization of the repertoire of hydrogen peroxide scavenging activities in fission yeast suggests that Tpx1 is the only enzyme with sufficient sensitivity for peroxides and cellular abundance as to control the low levels produced during aerobic growth, catalase being the next barrier of detoxification when the steady-state levels of peroxides are increased in Δtpx1 cells. Gpx1, the only glutathione peroxidase encoded by the S. pombe genome, only has a minor secondary role when extracellular peroxides are added. Our study proposes non-overlapping roles for the different hydrogen peroxide scavenging activities of this eukaryotic organism.

DOI: 10.1111/mmi.12548
PubMed: 24521463

Affiliations:

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Le document en format XML

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<series><title level="j">Molecular microbiology</title>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aerobiosis (MeSH)</term>
<term>Anaerobiosis (MeSH)</term>
<term>Basic-Leucine Zipper Transcription Factors (metabolism)</term>
<term>Catalase (metabolism)</term>
<term>Gene Deletion (MeSH)</term>
<term>Gene Expression Regulation, Fungal (MeSH)</term>
<term>Hydrogen Peroxide (metabolism)</term>
<term>Oxygen (metabolism)</term>
<term>Pancreatitis-Associated Proteins (MeSH)</term>
<term>Peroxiredoxins (genetics)</term>
<term>Peroxiredoxins (metabolism)</term>
<term>Schizosaccharomyces (genetics)</term>
<term>Schizosaccharomyces (metabolism)</term>
<term>Schizosaccharomyces pombe Proteins (genetics)</term>
<term>Schizosaccharomyces pombe Proteins (metabolism)</term>
<term>Thioredoxin-Disulfide Reductase (genetics)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Anaérobiose (MeSH)</term>
<term>Aérobiose (MeSH)</term>
<term>Catalase (métabolisme)</term>
<term>Délétion de gène (MeSH)</term>
<term>Facteurs de transcription à motif basique et à glissière à leucines (métabolisme)</term>
<term>Oxygène (métabolisme)</term>
<term>Peroxirédoxines (génétique)</term>
<term>Peroxirédoxines (métabolisme)</term>
<term>Peroxyde d'hydrogène (métabolisme)</term>
<term>Protéines associées à la pancréatite (MeSH)</term>
<term>Protéines de Schizosaccharomyces pombe (génétique)</term>
<term>Protéines de Schizosaccharomyces pombe (métabolisme)</term>
<term>Régulation de l'expression des gènes fongiques (MeSH)</term>
<term>Schizosaccharomyces (génétique)</term>
<term>Schizosaccharomyces (métabolisme)</term>
<term>Thioredoxin-disulfide reductase (génétique)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Peroxiredoxins</term>
<term>Schizosaccharomyces pombe Proteins</term>
<term>Thioredoxin-Disulfide Reductase</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Basic-Leucine Zipper Transcription Factors</term>
<term>Catalase</term>
<term>Hydrogen Peroxide</term>
<term>Oxygen</term>
<term>Peroxiredoxins</term>
<term>Schizosaccharomyces pombe Proteins</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Schizosaccharomyces</term>
</keywords>
<keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Peroxirédoxines</term>
<term>Protéines de Schizosaccharomyces pombe</term>
<term>Schizosaccharomyces</term>
<term>Thioredoxin-disulfide reductase</term>
</keywords>
<keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Schizosaccharomyces</term>
</keywords>
<keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Catalase</term>
<term>Facteurs de transcription à motif basique et à glissière à leucines</term>
<term>Oxygène</term>
<term>Peroxirédoxines</term>
<term>Peroxyde d'hydrogène</term>
<term>Protéines de Schizosaccharomyces pombe</term>
<term>Schizosaccharomyces</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Aerobiosis</term>
<term>Anaerobiosis</term>
<term>Gene Deletion</term>
<term>Gene Expression Regulation, Fungal</term>
<term>Pancreatitis-Associated Proteins</term>
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<term>Aérobiose</term>
<term>Délétion de gène</term>
<term>Protéines associées à la pancréatite</term>
<term>Régulation de l'expression des gènes fongiques</term>
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<front><div type="abstract" xml:lang="en">The main peroxiredoxin in Schizosaccharomyces pombe, Tpx1, is important to sustain aerobic growth, and cells lacking this protein are only able to grow on solid plates under anaerobic conditions. We have found that deletion of the gene coding for thioredoxin reductase, trr1, is a suppressor of the sensitivity to aerobic growth of Δtpx1 cells, so that cells lacking both proteins are able to grow on solid plates in the presence of oxygen. We have investigated this suppression effect, and determined that it depends on the presence of catalase, which is constitutively expressed in Δtrr1 cells in a transcription factor Pap1-dependent manner. A complete characterization of the repertoire of hydrogen peroxide scavenging activities in fission yeast suggests that Tpx1 is the only enzyme with sufficient sensitivity for peroxides and cellular abundance as to control the low levels produced during aerobic growth, catalase being the next barrier of detoxification when the steady-state levels of peroxides are increased in Δtpx1 cells. Gpx1, the only glutathione peroxidase encoded by the S. pombe genome, only has a minor secondary role when extracellular peroxides are added. Our study proposes non-overlapping roles for the different hydrogen peroxide scavenging activities of this eukaryotic organism. </div>
</front>
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<Title>Molecular microbiology</Title>
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<Abstract><AbstractText>The main peroxiredoxin in Schizosaccharomyces pombe, Tpx1, is important to sustain aerobic growth, and cells lacking this protein are only able to grow on solid plates under anaerobic conditions. We have found that deletion of the gene coding for thioredoxin reductase, trr1, is a suppressor of the sensitivity to aerobic growth of Δtpx1 cells, so that cells lacking both proteins are able to grow on solid plates in the presence of oxygen. We have investigated this suppression effect, and determined that it depends on the presence of catalase, which is constitutively expressed in Δtrr1 cells in a transcription factor Pap1-dependent manner. A complete characterization of the repertoire of hydrogen peroxide scavenging activities in fission yeast suggests that Tpx1 is the only enzyme with sufficient sensitivity for peroxides and cellular abundance as to control the low levels produced during aerobic growth, catalase being the next barrier of detoxification when the steady-state levels of peroxides are increased in Δtpx1 cells. Gpx1, the only glutathione peroxidase encoded by the S. pombe genome, only has a minor secondary role when extracellular peroxides are added. Our study proposes non-overlapping roles for the different hydrogen peroxide scavenging activities of this eukaryotic organism. </AbstractText>
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<Initials>A</Initials>
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<ForeName>Elena</ForeName>
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<tree><noCountry><name sortKey="Ayte, Jose" sort="Ayte, Jose" uniqKey="Ayte J" first="José" last="Ayté">José Ayté</name>
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<name sortKey="Calvo, Isabel A" sort="Calvo, Isabel A" uniqKey="Calvo I" first="Isabel A" last="Calvo">Isabel A. Calvo</name>
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<name sortKey="Domenech, Alba" sort="Domenech, Alba" uniqKey="Domenech A" first="Alba" last="Domènech">Alba Domènech</name>
<name sortKey="Garcia Santamarina, Sarela" sort="Garcia Santamarina, Sarela" uniqKey="Garcia Santamarina S" first="Sarela" last="García-Santamarina">Sarela García-Santamarina</name>
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<country name="Espagne"><region name="Catalogne"><name sortKey="Paulo, Esther" sort="Paulo, Esther" uniqKey="Paulo E" first="Esther" last="Paulo">Esther Paulo</name>
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	Serveur d'exploration sur la détoxication des champignons
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Serveur d'exploration sur la détoxication des champignons

A genetic approach to study H2O2 scavenging in fission yeast--distinct roles of peroxiredoxin and catalase.

A genetic approach to study H2O2 scavenging in fission yeast--distinct roles of peroxiredoxin and catalase.

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